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Dev Cell. 2017 Mar 13;40(5):427-428. doi: 10.1016/j.devcel.2017.02.024.

RNA Methylation Clears the Way.

Author information

1
Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
2
Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: antonio.giraldez@yale.edu.

Abstract

During the maternal-to-zygotic transition, maternal mRNAs are cleared by multiple distinct but interrelated pathways. A recent study in Nature by Zhao et al. (2017) finds that YTHDF2, a reader of N6- methylation, facilitates maternal mRNA decay, introducing an additional facet of control over transcript fate and developmental reprogramming.

PMID:
28292421
DOI:
10.1016/j.devcel.2017.02.024
[Indexed for MEDLINE]
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