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Curr Opin Genet Dev. 2017 Apr;43:101-109. doi: 10.1016/j.gde.2017.02.003. Epub 2017 Mar 2.

DNA methylation homeostasis in human and mouse development.

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Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK.
Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. Electronic address:


The molecular pathways that regulate gain and loss of DNA methylation during mammalian development need to be tightly balanced to maintain a physiological equilibrium. Here we explore the relative contributions of the different pathways and enzymatic activities involved in methylation homeostasis in the context of genome-wide and locus-specific epigenetic reprogramming in mammals. An adaptable epigenetic machinery allows global epigenetic reprogramming to concur with local maintenance of critical epigenetic memory in the genome, and appears to regulate the tempo of global reprogramming in different cell lineages and species.

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