Format

Send to

Choose Destination
J Innate Immun. 2017;9(3):250-261. doi: 10.1159/000455857. Epub 2017 Feb 22.

Inflammation: A Double-Edged Sword in the Response to Pseudomonas aeruginosa Infection.

Author information

1
Yale University School of Medicine, New Haven, CT, USA.

Abstract

The Gram-negative opportunistic pathogen Pseudomonas aeruginosa exploits failures of barrier defense and innate immunity to cause acute infections at a range of anatomic sites. We review the defense mechanisms that normally protect against P. aeruginosa pulmonary infection, as well as the bacterial products and activities that trigger their activation. Innate immune recognition of P. aeruginosa is critical for pathogen clearance; nonetheless, inflammation is also associated with pathogen persistence and poor host outcomes. We describe P. aeruginosa adaptations that improve this pathogen's fitness in the inflamed airway, and briefly discuss strategies to manipulate inflammation to benefit the host. Such adjunct therapies may become increasingly important in the treatment of acute and chronic infections caused by this multi-drug-resistant pathogen.

KEYWORDS:

Host defense; Inflammasome; Inflammation; Innate immunity; Pneumonia; Pseudomonas aeruginosa

PMID:
28222444
PMCID:
PMC5469373
DOI:
10.1159/000455857
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
Loading ...
Support Center