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Curr Opin Microbiol. 2017 Feb;35:70-77. doi: 10.1016/j.mib.2017.01.012. Epub 2017 Feb 16.

Emerging insights into the biology of typhoid toxin.

Author information

1
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, United States.
2
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, United States. Electronic address: jorge.galan@yale.edu.

Abstract

Typhoid toxin is a unique A2B5 exotoxin and an important virulence factor for Salmonella Typhi, the cause of typhoid fever. In the decade since its initial discovery, great strides have been made in deciphering the unusual biological program of this toxin, which is fundamentally different from related toxins in many ways. Purified typhoid toxin administered to laboratory animals causes many of the symptoms of typhoid fever, suggesting that typhoid toxin is a central factor in this disease. Further advances in understanding the biology of this toxin will help guide the development of badly needed diagnostics and therapeutic interventions that target this toxin to detect, prevent or treat typhoid fever.

PMID:
28213043
PMCID:
PMC5484737
DOI:
10.1016/j.mib.2017.01.012
[Indexed for MEDLINE]
Free PMC Article

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