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Adv Pharmacol. 2017;78:323-350. doi: 10.1016/bs.apha.2016.08.001. Epub 2016 Oct 14.

Vascular Cells in Blood Vessel Wall Development and Disease.

Author information

1
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, United States.
2
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, United States. Electronic address: daniel.greif@yale.edu.

Abstract

The vessel wall is composed of distinct cellular layers, yet communication among individual cells within and between layers results in a dynamic and versatile structure. The morphogenesis of the normal vascular wall involves a highly regulated process of cell proliferation, migration, and differentiation. The use of modern developmental biological and genetic approaches has markedly enriched our understanding of the molecular and cellular mechanisms underlying these developmental events. Additionally, the application of similar approaches to study diverse vascular diseases has resulted in paradigm-shifting insights into pathogenesis. Further investigations into the biology of vascular cells in development and disease promise to have major ramifications on therapeutic strategies to combat pathologies of the vasculature.

KEYWORDS:

Blood vessel wall; Pericytes; Tunica media; Vascular development; Vascular disease; Vascular mural cells; Vascular smooth muscle cells

PMID:
28212800
PMCID:
PMC5559712
DOI:
10.1016/bs.apha.2016.08.001
[Indexed for MEDLINE]
Free PMC Article

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