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J Clin Neurosci. 2017 May;39:63-67. doi: 10.1016/j.jocn.2016.12.049. Epub 2017 Feb 10.

MRI findings of optic pathway involvement in Miller Fisher syndrome in 3 pediatric patients and a review of the literature.

Author information

1
Department of Diagnostic Radiology, Yale School of Medicine, Box 208042, Tompkins East 2, 333 Cedar St, New Haven, CT 06520-8042, United States. Electronic address: ajay.malhotra@yale.edu.
2
Griffith University, Brisbane, Australia. Electronic address: mia.zhang.m@gmail.com.
3
Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT, United States. Electronic address: xiao.wu@yale.edu.
4
University of North Carolina, School of Public Health, Chapel Hill, NC, United States. Electronic address: s_jindal3@yahoo.com.
5
Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT, United States. Electronic address: david.durand@yale.edu.
6
Department of Pediatrics (Neurology) and of Neurology, Yale School of Medicine, New Haven, CT, United States. Electronic address: naila.makhani@yale.edu.

Abstract

BACKGROUND:

Miller Fisher syndrome (MFS) is a rare demyelinating condition which may have involvement of cranial nerves. There are a few case reports of optic pathway involvement in children. We describe 3 patients with optic pathway enhancement in pediatric patients with MFS.

CASE SERIES:

We retrospectively reviewed brain imaging findings in 17 pediatric patients with of Guillain-Barré syndrome (GBS) meeting Brighton criteria who had brain MRIs performed during their acute illness. Cranial nerve enhancement was seen in 6/17 patients and optic nerve/chiasm enhancement was seen in 3 patients.

CONCLUSION:

Cranial nerve enhancement and optic pathway in particular, can be seen in patients with MFS. Imaging findings do not always correlate with clinical manifestations of cranial nerve involvement.

KEYWORDS:

Guillain–Barré syndrome; MRI; Miller Fisher syndrome; Optic involvement

PMID:
28209311
DOI:
10.1016/j.jocn.2016.12.049
[Indexed for MEDLINE]
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