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Occup Environ Med. 2017 Jul;74(7):502-510. doi: 10.1136/oemed-2016-103931. Epub 2017 Feb 15.

Occupational exposure to pesticides and other biocides and risk of thyroid cancer.

Author information

1
Chongqing Safety Engineering Institute, Chongqing University of Science and Technology, Chongqing, China.
2
Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
3
Department of Environmental and Occupational Health, University of Montreal, Montreal, Canada.
4
Department of Surgery, Section of Surgical Outcomes and Epidemiology, Yale School of Medicine, New Haven, Connecticut, USA.
5
Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.
6
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
7
Department of Surgery and Yale Cancer Center, Yale School of Medicine, Yale New Haven Hospital, New Haven, Connecticut, USA.

Abstract

OBJECTIVES:

To assess the associations between occupational exposure to biocides and pesticides and risk of thyroid cancer.

METHODS:

Using data from a population-based case-control study involving 462 incident thyroid cancer cases and 498 controls in Connecticut collected in 2010-2011, we examined the association with occupational exposure to biocides and pesticides through a job-exposure matrix. We used unconditional logistic regression models to estimate OR and 95% CI, adjusting for potential confounders.

RESULTS:

Individuals who were occupationally ever exposed to biocides had an increased risk of thyroid cancer (OR=1.65, 95% CI 1.16 to 2.35), and the highest risk was observed for the high cumulative probability of exposure (OR=2.18, 95% CI 1.28 to 3.73). The observed associations were similar when we restricted to papillary thyroid cancer and well-differentiated thyroid cancer. Stronger associations were observed for thyroid microcarcinomas (tumour size ≤1 cm). No significant association was observed for occupational exposure to pesticides.

CONCLUSIONS:

Our study provides the first evidence linking occupational exposure to biocides and risk of thyroid cancer. The results warrant further investigation.

KEYWORDS:

job-exposure matrix; occupational exposure; thyroid cancer

PMID:
28202579
PMCID:
PMC5572578
DOI:
10.1136/oemed-2016-103931
[Indexed for MEDLINE]
Free PMC Article

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