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Curr Opin Genet Dev. 2017 Apr;43:93-100. doi: 10.1016/j.gde.2017.01.004. Epub 2017 Feb 9.

More to cohesin than meets the eye: complex diversity for fine-tuning of function.

Author information

1
Research Department of Cancer Biology, Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, United Kingdom.
2
Research Department of Cancer Biology, Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, United Kingdom. Electronic address: s.hadjur@ucl.ac.uk.

Abstract

Recent years have witnessed a dramatic expansion in our understanding of gene control. It is now widely appreciated that the spatial organization of the genome and the manner in which genes and regulatory elements are embedded therein has a critical role in facilitating the regulation of gene expression. The loop structures that underlie chromosome organization are anchored by cohesin complexes. Several components of the cohesin complex have multiple paralogs, leading to different levels of cohesin complex variants in cells. Here we review the current literature around cohesin variants and their known functions. We further discuss how variation in cohesin complex composition can result in functional differences that can impact genome organization and determine cell fate.

PMID:
28189962
DOI:
10.1016/j.gde.2017.01.004
[Indexed for MEDLINE]

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