Format

Send to

Choose Destination
See comment in PubMed Commons below
Tremor Other Hyperkinet Mov (N Y). 2016 Dec 15;6:431. doi: 10.7916/D86H4HRN. eCollection 2016.

A Comparison Study of Cognitive and Neuropsychiatric Features of Essential Tremor and Parkinson's Disease.

Author information

1
Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.
2
Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain; Department of Medicine, Faculty of Medicine, Complutense University, Madrid, Spain.
3
Department of Basic Psychology II (Cognitive Processes), Faculty of Psychology, Complutense University, Madrid, Spain.
4
Faculty of Biosanitary Sciences, Francisco de Vitoria University, Pozuelo de Alarcón, Madrid, Spain.
5
Department of Neurology, Yale School of Medicine, New Haven, CT, USA; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA; Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine and Yale School of Public Health, New Haven, CT, USA.
6
Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain; Department of Medicine, Faculty of Medicine, Complutense University, Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

Abstract

BACKGROUND:

Essential tremor (ET) and Parkinson's disease (PD) are two of the most common movement disorders. Leaving aside their motor features, these two conditions share several non-motor features, including cognitive dysfunction and personality changes. However, there are few data comparing the cognitive and personality profiles of ET with PD. Here we compare the cognitive and personality profiles of the two diseases.

METHODS:

Thirty-two consecutive non-demented ET patients (13 females and 19 males) (67.7±9.8 years), 32 non-demented PD patients (13 females and 19 males) (67.7±9.5 years), and 32 healthy matched controls (14 females and 18 males) (67.9±10.1 years) underwent a neuropsychological test battery, including a global cognitive assessment and tests of attention, executive function, memory, language, and visuospatial function, as well as the Personality Assessment Inventory. Multivariable linear regression analyses were performed, adjusted for age, sex, years of education, medications that potentially affect cognitive function, number of medications, and the 17-item Hamilton Depression Rating Scale Total Score.

RESULTS:

Neuropsychological scores were similar in PD and ET patients, but patients with disease performed more poorly than control subjects in cognitive tasks such as attention, executive function, memory, and naming.

DISCUSSION:

ET and PD exhibited similar deficits in specific aspects of neuropsychological functioning, particularly those thought to rely on the integrity of the prefrontal cortex, and this suggests involvement of frontocerebellar circuits. These findings further challenge the traditional view of ET as a benign and monosymptomatic disorder.

KEYWORDS:

Essential tremor; Parkinson’s disease; cerebellum; cognitive impairment; movement disorders; neurobehavioral manifestations; neuropsychology; thalamus

Conflict of interest statement

Funding: Dr. Benito-León is supported by the National Institutes of Health, Bethesda, MD, USA (NINDS #R01 NS39422), the Commission of the European Union (grant ICT-2011-287739, NeuroTREMOR), and the Spanish Health Research Agency (grant FIS PI12/01602). Dr. Louis has received research support from the National Institutes of Health: NINDS #R01 NS039422 (principal investigator), NINDS #R01 NS094607 (principal investigator), NINDS #R01 NS073872 (principal investigator), NINDS #R01 NS085136 (principal investigator), NINDS #R01 NS046346 (principal investigator), and NINDS #R01 NS088257 (principal investigator). Dr. Romero is supported by the Commission of the European Union (grant ICT-2011-287739, NeuroTREMOR). Conflicts of Interest: The authors report no conflict of interest. Ethics Statement: This study was performed in accordance with the ethical standards detailed in the Declaration of Helsinki. The authors’ institutional ethics committee has approved this study and all patients have provided written informed consent.

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Center for Digital Research and Scholarship, Columbia University Icon for PubMed Central
    Loading ...
    Support Center