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Mol Biol Cell. 2017 Jan 15;28(2):229-232. doi: 10.1091/mbc.E16-07-0508.

The secretory pathway at 50: a golden anniversary for some momentous grains of silver.

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  • 1Department of Surgery, University of Chicago, Chicago, IL 60637-1470.
  • 2Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520-8026


The secretory pathway along which newly synthesized secretory and membrane proteins traffic through the cell was revealed in two articles published 50 years ago. This discovery was the culmination of decades of effort to unite the power of biochemical and morphological methodologies in order to elucidate the dynamic nature of the cell's biosynthetic machinery. The secretory pathway remains a central paradigm of modern cell biology. Its elucidation 50 years ago inspired tremendous multidisciplinary and on-going efforts to understand the machinery that makes it run, the adaptations that permit it to serve the needs of specialized cell types, and the pathological consequences that arise when it is perturbed.

[Available on 2017-03-30]
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