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Cornea. 2017 Mar;36(3):372-374. doi: 10.1097/ICO.0000000000001139.

Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma.

Author information

1
*Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT; †New England Retina Associates, Hamden, CT; and Departments of ‡Pathology; and §Medicine, Yale University School of Medicine, New Haven, CT.

Abstract

PURPOSE:

To report a case of asymmetric deep stromal keratopathy in a patient with multiple myeloma.

METHODS:

Case report and literature review.

RESULTS:

An 85-year-old woman was found to have progressive visually significant left-sided deep stromal opacity in the setting of monoclonal gammopathy. Hematologic workup resulted in a diagnosis of IgG kappa multiple myeloma. Histopathology was significant for semicrystalline deposits in the posterior stroma. The patient's visual acuity improved to 20/50 7 months after penetrating keratoplasty. A similar deep stromal lesion appeared in the right eye 2 years after initial presentation.

CONCLUSIONS:

We present an unusual case of paraproteinemic keratopathy with a uniquely asymmetric presentation that resulted in a diagnosis of multiple myeloma.

PMID:
28079685
DOI:
10.1097/ICO.0000000000001139
[Indexed for MEDLINE]

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