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Sci Rep. 2017 Jan 12;7:38763. doi: 10.1038/srep38763.

Improving the Concentrations of the Active Components in the Herbal Tea Ingredient, Uraria crinita: The Effect of Post-harvest Oven-drying Processing.

Author information

1
Institute of Pharmacology, National Yang-Ming University, College of Medicine, Taipei, Taiwan.
2
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
3
Department of Nursing, Chung-Jen Junior College of Nursing, Health Sciences and Management, Chia-Yi, Taiwan.
4
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States.
5
Modern Research Center for Traditional Chinese Medicine of Shanxi University, Shanxi, China.
6
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taiwan.
7
Research Center for Industry of Human Ecology, Graduate Institute of Health-Industry Technology and Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan.
8
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.

Abstract

Uraria crinita is widely used as a popular folk drink; however, little is known about how the post-harvest operations affect the chemical composition and bioactivity of UC. We assessed three drying methods (Oven-drying, Air-drying, Sun-drying), as well as the Oven-drying temperature using metabolomics approaches and bioactivity assays. The samples processed at 40 degree show a greater effect on the levels of estrogen receptor-alpha activity and nuclear factor erythroid 2-related factor 2 activity, anti-oxidative activity, and cyclooxygenase-2 inhibition compared with the other samples. A multivariate analysis showed a clear separation between the 40 degree Oven-dried samples and the other samples, which is consistent with the results of bioactivity assay. These results are ascribed to at least two-fold increase in the concentrations of flavonoids, spatholosineside A and triterpenoids in the oven-dried samples compared with the other groups. The proposed Oven-drying method at 40 degree results in an improved quality of UC.

PMID:
28079108
PMCID:
PMC5227699
DOI:
10.1038/srep38763
[Indexed for MEDLINE]
Free PMC Article

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