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Sci Rep. 2017 Jan 12;7:38763. doi: 10.1038/srep38763.

Improving the Concentrations of the Active Components in the Herbal Tea Ingredient, Uraria crinita: The Effect of Post-harvest Oven-drying Processing.

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Institute of Pharmacology, National Yang-Ming University, College of Medicine, Taipei, Taiwan.
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Department of Nursing, Chung-Jen Junior College of Nursing, Health Sciences and Management, Chia-Yi, Taiwan.
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States.
Modern Research Center for Traditional Chinese Medicine of Shanxi University, Shanxi, China.
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taiwan.
Research Center for Industry of Human Ecology, Graduate Institute of Health-Industry Technology and Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan.
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.


Uraria crinita is widely used as a popular folk drink; however, little is known about how the post-harvest operations affect the chemical composition and bioactivity of UC. We assessed three drying methods (Oven-drying, Air-drying, Sun-drying), as well as the Oven-drying temperature using metabolomics approaches and bioactivity assays. The samples processed at 40 degree show a greater effect on the levels of estrogen receptor-alpha activity and nuclear factor erythroid 2-related factor 2 activity, anti-oxidative activity, and cyclooxygenase-2 inhibition compared with the other samples. A multivariate analysis showed a clear separation between the 40 degree Oven-dried samples and the other samples, which is consistent with the results of bioactivity assay. These results are ascribed to at least two-fold increase in the concentrations of flavonoids, spatholosineside A and triterpenoids in the oven-dried samples compared with the other groups. The proposed Oven-drying method at 40 degree results in an improved quality of UC.

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