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Neurology. 2017 Feb 7;88(6):595-602. doi: 10.1212/WNL.0000000000003587. Epub 2017 Jan 6.

Acute plasma tau relates to prolonged return to play after concussion.

Author information

1
From the National Institute of Nursing Research (J.G., W.L.), NIH, Bethesda, MD; Department of Emergency Medicine (K.M.-B., J.B.), University of Rochester School of Medicine and Dentistry, Rochester, NY; and Quanterix Corporation (A.J.), Lexington, MA. gillj@mail.nih.gov.
2
From the National Institute of Nursing Research (J.G., W.L.), NIH, Bethesda, MD; Department of Emergency Medicine (K.M.-B., J.B.), University of Rochester School of Medicine and Dentistry, Rochester, NY; and Quanterix Corporation (A.J.), Lexington, MA.

Abstract

OBJECTIVE:

To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP).

METHODS:

Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at baseline. SRC athletes were grouped by long (>10 days, n = 23) and short (≤10 days, n = 18) RTP. Total tau was measured using an ultrasensitive immunoassay.

RESULTS:

Both SRC and athlete controls had significantly higher mean tau at baseline compared to nonathlete healthy controls (F101,3 = 19.644, p < 0.01). Compared to SRC athletes with short RTP, those with long RTP had higher tau concentrations overall, after controlling for sex (F39,1 = 3.59, p = 0.022), compared to long RTP athletes, at 6 (p < 0.01), 24 (p < 0.01), and 72 hours (p = 0.02). Receiver operator characteristic analyses showed that higher plasma tau 6 hours post-SRC was a significant predictor of RTP >10 days (area under the curve 0.81; 95% confidence interval 0.62-0.97, p = 0.01).

CONCLUSIONS:

Elevated plasma tau concentration within 6 hours following a SRC was related to having a prolonged RTP, suggesting that tau levels may help inform RTP.

PMID:
28062722
PMCID:
PMC5304458
DOI:
10.1212/WNL.0000000000003587
[Indexed for MEDLINE]
Free PMC Article

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