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Cold Spring Harb Perspect Med. 2017 May 1;7(5). pii: a024075. doi: 10.1101/cshperspect.a024075.

Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity.

Author information

1
Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06536.

Abstract

In Alzheimer's disease (AD), insoluble and fibrillary amyloid-β (Aβ) peptide accumulates in plaques. However, soluble Aβ oligomers are most potent in creating synaptic dysfunction and loss. Therefore, receptors for Aβ oligomers are hypothesized to be the first step in a neuronal cascade leading to dementia. A number of cell-surface proteins have been described as Aβ binding proteins, and one or more are likely to mediate Aβ oligomer toxicity in AD. Cellular prion protein (PrPC) is a high-affinity Aβ oligomer binding site, and a range of data delineates a signaling pathway leading from Aβ complexation with PrPC to neuronal impairment. Further study of Aβ binding proteins will define the molecular basis of this crucial step in AD pathogenesis.

PMID:
27940601
PMCID:
PMC5411685
DOI:
10.1101/cshperspect.a024075
[Indexed for MEDLINE]
Free PMC Article

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