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Cell Metab. 2017 Feb 7;25(2):242-247. doi: 10.1016/j.cmet.2016.10.022. Epub 2016 Nov 23.

Exercise Mimetics: Impact on Health and Performance.

Author information

1
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
2
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: evans@salk.edu.

Abstract

The global epidemic of obesity and its associated chronic diseases is largely attributed to an imbalance between caloric intake and energy expenditure. While physical exercise remains the best solution, the development of muscle-targeted "exercise mimetics" may soon provide a pharmaceutical alternative to battle an increasingly sedentary lifestyle. At the same time, these advances are fueling a raging debate on their escalating use as performance-enhancing drugs in high-profile competitions such as the Olympics.

KEYWORDS:

exercise; exercise mimetics; skeletal muscle

PMID:
27889389
PMCID:
PMC5555683
DOI:
10.1016/j.cmet.2016.10.022
[Indexed for MEDLINE]
Free PMC Article

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