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J Hum Genet. 2017 Mar;62(3):413-418. doi: 10.1038/jhg.2016.145. Epub 2016 Nov 24.

A combined linkage and association strategy identifies a variant near the GSTP1 gene associated with BMI in the Mexican population.

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Programa de Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, México City, México.
Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/Instituto Nacional de Medicina Genómica (INMEGEN), México City, México.
Facultad de Medicina, Universidad Autónoma de Sinaloa, Sinaloa, México.
Departamento de Genómica Computacional, INMEGEN, México City, México.
Departamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez (INCICh), México City, México.
Laboratorio de Enfermedades Cardiovasculares, INMEGEN, México City, México.
Clínica Integral de Cirugía para la Obesidad y Enfermedades Metabólicas, Hospital General 'Dr Rubén Leñero', México City, México.
Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Departmento de Atención a la salud, Universidad Autónoma Metropolitana-Xochimilco, México City, México.
Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México.


Obesity is a major public health concern in Mexico and worldwide. Although the estimated heritability is high, common variants identified by genome-wide association studies explain only a small proportion of this heritability. A combination of linkage and association strategies could be a more robust and powerful approach to identify other obesity-susceptibility variants. We thus sought to identify novel genetic variants associated with obesity-related traits in the Mexican population by combining these methods. We performed a genome-wide linkage scan for body mass index (BMI) and other obesity-related phenotypes in 16 Mexican families using the Sequential Oligogenic Linkage Analysis Routines Program. Associated single-nucleotide polymorphisms (SNPs) were tested for associations in an independent cohort. Two suggestive BMI-linkage peaks (logarithm of odds ⩾1.5) were observed at chromosomal regions 11q13 and 13q22. Only rs614080 in the 11q13 region was significantly associated with BMI and related traits in these families. This association was also significant in an independent cohort of Mexican adults. Moreover, this variant was significantly associated with GSTP1 gene expression levels in adipose tissue. In conclusion, the rs614080 SNP near the GSTP1 gene was significantly associated with BMI and GSTP1 expression levels in the Mexican population.

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