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J Invest Dermatol. 2017 Feb;137(2):282-287. doi: 10.1016/j.jid.2016.08.033. Epub 2016 Nov 12.

Preclinical Advances with Multiphoton Microscopy in Live Imaging of Skin Cancers.

Author information

1
Department of Genetics, Yale School of Medicine, New Haven, Connecticut, USA. Electronic address: thomasyang.sun@yale.edu.
2
Departments of Immunobiology and Laboratory Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
3
Department of Genetics, Yale School of Medicine, New Haven, Connecticut, USA; Departments of Dermatology and Cell Biology, Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, USA. Electronic address: Valentina.Greco@yale.edu.

Abstract

Conventional, static analyses have historically been the bedrock and tool of choice for the study of skin cancers. Over the past several years, in vivo imaging of tumors using multiphoton microscopy has emerged as a powerful preclinical tool for revealing detailed cellular behaviors from the earliest moments of tumor development to the final steps of metastasis. Multiphoton microscopy allows for deep tissue penetration with relatively minor phototoxicity, rendering it an effective tool for the long-term observation of tumor evolution. This review highlights some of the recent preclinical insights gained using multiphoton microscopy and suggests future advances that could enhance its power in revealing the mysteries of skin tumor biology.

PMID:
27847119
PMCID:
PMC5258832
DOI:
10.1016/j.jid.2016.08.033
[Indexed for MEDLINE]
Free PMC Article

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