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Behav Brain Res. 2017 Mar 1;320:356-364. doi: 10.1016/j.bbr.2016.11.009. Epub 2016 Nov 8.

Effects of alcohol on c-Myc protein in the brain.

Author information

1
Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, United States.
2
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27106, United States.
3
School of Engineering and Department of Computer Science, Baylor University Waco, TX 76978, United States.
4
Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, United States; Departments of Neurology and Radiation Medicine, Division of Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, United States. Electronic address: raberj@ohsu.edu.

Abstract

Alcoholism is a disorder categorized by significant impairment that is directly related to persistent and extreme use of alcohol. The effects of alcoholism on c-Myc protein expression in the brain have been scarcely studied. This is the first study to investigate the role different characteristics of alcoholism have on c-Myc protein in the brain. We analyzed c-Myc protein in the hypothalamus and amygdala from five different animal models of alcohol abuse. c-Myc protein was increased following acute ethanol exposure in a mouse knockout model and following chronic ethanol consumption in vervet monkeys. We also observed increases in c-Myc protein exposure in animals that are genetically predisposed to alcohol and methamphetamine abuse. Lastly, c-Myc protein was increased in animals that were acutely exposed to methamphetamine when compared to control treated animals. These results suggest that in substance abuse c-Myc plays an important role in the brain's response.

KEYWORDS:

Alcoholism; Phosphorylation; Preference; Withdrawal; c-Myc

PMID:
27832980
PMCID:
PMC5915357
DOI:
10.1016/j.bbr.2016.11.009
[Indexed for MEDLINE]
Free PMC Article

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