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Trends Cancer. 2016 Jul;2(7):365-377. Epub 2016 Jun 27.

Oncogene-directed alterations in cancer cell metabolism.

Author information

1
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA, 06510.
2
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA, 06510; Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA, 06510.

Abstract

Oncogenes are key drivers of tumor growth. Although several cancer-driving mechanisms have been identified, the role of oncogenes in shaping metabolic patterns in cancer cells is only beginning to be appreciated. Recent studies show that oncogenes directly regulate critical metabolic enzymes and metabolic signaling pathways. Here, we present evidence for oncogene-directed cancer metabolic regulation and discuss the importance of identifying underlying mechanisms that can be targeted for developing precision cancer therapies.

KEYWORDS:

Oncogene; metabolic pathways; precision cancer therapies; tumor growth

PMID:
27822561
PMCID:
PMC5096652
DOI:
10.1016/j.trecan.2016.06.002
[Indexed for MEDLINE]
Free PMC Article

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