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Cancer Discov. 2016 Nov;6(11):1212-1214.

TERT Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin Interactions.

Author information

1
Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas.
2
Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas. jerry.shay@utsouthwestern.edu.

Abstract

Although single-nucleotide somatic mutations in the proximal promoter of the human telomerase reverse transcriptase (TERT) gene create novel consensus sequences for transcription factors that enhance TERT expression, the precise mechanism of how telomerase is reactivated in cancer cells remains poorly understood. In this issue, Akıncılar and colleagues identify a potential mechanism of TERT reactivation that is mediated by a novel long-range chromatin interaction between the TERT promoter on chromosome 5p and a 300-kb upstream region. This permits recruitment of the transcription factor GABPA in mutant TERT promoters but not in wild-type promoters. Cancer Discov; 6(11); 1212-4. ©2016 AACRSee related article by Akıncılar and colleagues, p. 1276.

PMID:
27807101
PMCID:
PMC5111399
DOI:
10.1158/2159-8290.CD-16-1050
[Indexed for MEDLINE]
Free PMC Article

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