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Cell. 2016 Oct 20;167(3):606-609. doi: 10.1016/j.cell.2016.09.030.

p62 in Cancer: Signaling Adaptor Beyond Autophagy.

Author information

1
Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: jmoscat@sbpdiscovery.org.
2
Laboratory of Signal Transduction and Gene Regulation Departments of Pharmacology and Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla Ca 92093, USA.
3
Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.

PMID:
27768885
PMCID:
PMC5114003
DOI:
10.1016/j.cell.2016.09.030
[Indexed for MEDLINE]
Free PMC Article

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