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Plast Reconstr Surg Glob Open. 2016 Sep 16;4(9):e1032. eCollection 2016 Sep.

A Unique Case of Allogeneic Fat Grafting Between Brothers.

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Section of Plastic and Reconstructive Surgery, Yale University School of Medicine, New Haven, Conn.; Department of Dermatology, Yale University School of Medicine, New Haven, Conn.; and Yale University School of Medicine, New Haven, Conn.


We present a case of a 65-year-old man with cutaneous T-cell lymphoma treated with radiation therapy and an allogeneic hematopoietic stem cell transplant from his human leukocyte antigen-matched brother. Engraftment was successful, but the patient went on to develop painful, radiation-induced ulcers. The ulcers were fat-allografted using liposuctioned fat from his brother because of the patient's unique chimeric state. Postprocedure follow-up revealed epithelialization of the ulcer sites and significant improvement in neuropathic pain. Our unique case study supports the use of fat grafting for its restorative purposes and for its ability to alleviate chronic neuropathic pain. Additionally, it appears that our case provides a basis of a general approach to the treatment of radiation-induced ulcers in chimeric patients with lymphoid malignancies.

Conflict of interest statement

The authors have no financial interest to declare in relation to the content of this article. The article processing fees will be paid for by the authors.

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