Format

Send to

Choose Destination
See comment in PubMed Commons below
Brain Imaging Behav. 2016 Oct 13. [Epub ahead of print]

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.

Guadalupe T1,2, Mathias SR3, vanErp TG4, Whelan CD5,6, Zwiers MP7, Abe Y8, Abramovic L9, Agartz I10,11,12, Andreassen OA10,13, Arias-Vásquez A14,15,16, Aribisala BS17,18, Armstrong NJ19,20, Arolt V21, Artiges E22, Ayesa-Arriola R23,24, Baboyan VG25, Banaschewski T26, Barker G27, Bastin ME18,28,29,30, Baune BT31, Blangero J32,33, Bokde AL34, Boedhoe PS35,36,37, Bose A38, Brem S39,40, Brodaty H41, Bromberg U42, Brooks S43, Büchel C42, Buitelaar J16,44,45, Calhoun VD46,47, Cannon DM48, Cattrell A49, Cheng Y50, Conrod PJ51,52, Conzelmann A53,54, Corvin A55, Crespo-Facorro B23,24, Crivello F56, Dannlowski U21,57, de Zubicaray GI58, de Zwarte SM9, Deary IJ28, Desrivières S49, Doan NT10,13, Donohoe G59,60, Dørum ES13,61,62, Ehrlich S63,64,65, Espeseth T13,66, Fernández G16,44, Flor H67, Fouche JP68, Frouin V69, Fukunaga M70, Gallinat J71, Garavan H72, Gill M55,73, Suarez AG74,75, Gowland P76, Grabe HJ77,78, Grotegerd D21, Gruber O79, Hagenaars S80, Hashimoto R81,82, Hauser TU83,84,85, Heinz A86, Hibar DP5, Hoekstra PJ87, Hoogman M14, Howells FM43, Hu H88, Hulshoff Pol HE9, Huyser C89,90, Ittermann B91, Jahanshad N25, Jönsson EG12,92, Jurk S93, Kahn RS9, Kelly S94, Kraemer B79, Kugel H95, Kwon JS96,97,98, Lemaitre H22, Lesch KP99,100, Lochner C101, Luciano M28, Marquand AF7,102, Martin NG103, Martínez-Zalacaín I104, Martinot JL105,106, Mataix-Cols D107, Mather K19, McDonald C48, McMahon KL108, Medland SE103, Menchón JM104,109,110, Morris DW59, Mothersill O55,59, Maniega SM18,29,30,80, Mwangi B111, Nakamae T8,112, Nakao T113, Narayanaswaamy JC38, Nees F67, Nordvik JE61, Onnink AM14, Opel N21, Ophoff R9,114, Paillère Martinot ML22,115, Papadopoulos Orfanos D69, Pauli P116, Paus T117, Poustka L26,118, Reddy JY38, Renteria ME103, Roiz-Santiáñez R23,24, Roos A101, Royle NA18,29,30,80, Sachdev P19, Sánchez-Juan P74,75, Schmaal L119, Schumann G49, Shumskaya E7,14, Smolka MN93, Soares JC120, Soriano-Mas C104,109,121, Stein DJ122, Strike LT123, Toro R124, Turner JA47,125,126, Tzourio-Mazoyer N56, Uhlmann A127, Hernández MV18,29,30,80, van den Heuvel OA36,37,35, van der Meer D87, van Haren NE9, Veltman DJ119, Venkatasubramanian G38, Vetter NC93, Vuletic D43, Walitza S83,40,128, Walter H86, Walton E63,125, Wang Z88, Wardlaw J18,29,30,80, Wen W19, Westlye LT13,62, Whelan R129, Wittfeld K130, Wolfers T14,44, Wright MJ103,131, Xu J50, Xu X50, Yun JY132, Zhao J133,134, Franke B14,15, Thompson PM5, Glahn DC135,136, Mazoyer B56, Fisher SE1,44, Francks C137,138.

Author information

1
Language & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
2
International Max Planck Research School for Language Sciences, Nijmegen, The Netherlands.
3
Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06519, USA.
4
Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
5
Imaging Genetics Center, Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
6
Molecular and Cellular Therapeutics, The Royal College of Surgeons, Dublin 2, Ireland.
7
Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
8
Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
9
Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.
10
NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
11
Department of Research and Development, Diakonhjemmet Hospital, Oslo, Norway.
12
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden.
13
NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
14
Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
15
Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
16
Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
17
Department of Computer Science, Lagos State University, Lagos, Nigeria.
18
Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
19
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales (UNSW), Sydney, Australia.
20
Mathematics and Statistics, Murdoch University, Murdoch, Australia.
21
Department of Psychiatry, University of Münster, Münster, Germany.
22
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes -Sorbonne Paris Cité, Paris, France.
23
Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
24
CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Santander, Spain.
25
Imaging Genetics Center, Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Los Angeles, USA.
26
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.
27
Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
28
Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.
29
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
30
Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK.
31
Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, 5005, Australia.
32
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
33
South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
34
Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, Dublin, Ireland.
35
Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.
36
Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, The Netherlands.
37
Neuroscience Campus Amsterdam, VU/VUMC, Amsterdam, The Netherlands.
38
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
39
University Clinic for and Adolescent Psychiatry UCCAP, University of Zurich, Zurich, Switzerland.
40
Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
41
Centre for Healthy Brain Ageing (CHeBA), & Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.
42
University Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistr. 52, 20246, Hamburg, Germany.
43
Department of Psychiatry, University of Cape Town, Cape Town, South Africa.
44
Donders Institute for Brain, Cognition and Behaviour, Raboud University, Nijmegen, The Netherlands.
45
Karakter Child and Adolescent Psychiatry, Radboud university medical center, Nijmegen, The Netherlands.
46
Departments of Electrical and Computer Engineering,Neurosciences, Computer Science, and Psychiatry, The University of New Mexico, Albuquerque, NM, USA.
47
The Mind Research Network, Albuquerque, NM, USA.
48
Centre for Neuroimaging, Cognition & Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, H91 TK33, Ireland.
49
Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
50
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
51
Department of Psychiatry, Universite de Montreal, CHU Ste Justine Hospital, Montréal, Canada.
52
Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
53
Department of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), University of Würzburg, Germany, Tübingen, Würzburg, Germany.
54
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
55
Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.
56
UMR5296 CNRS, CEA and University of Bordeaux, Bordeaux, France.
57
Department of Psychiatry, University of Marburg, Marburg, Germany.
58
Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane City, Australia.
59
Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition & Genomics Centre (NICOG), School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, SW4 794, Galway, Ireland.
60
Department of Psychiatry & trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
61
Sunnaas Rehabilitation Hospital HT, Nesodden, Norway.
62
Department of Psychology, University of Oslo, Oslo, Norway.
63
Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Dresden, Germany.
64
Department of Psychiatry, Massachusetts General Hospital, Boston, USA.
65
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, USA.
66
NORMENT - KG Jebsen Centre, Department of Psychology, University of Oslo, Oslo, Norway.
67
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
68
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
69
Neurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, France.
70
Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, Japan.
71
Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Martinistrasse 52, 20246, Hamburg, Germany.
72
Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, 05405, USA.
73
Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.
74
Service of Neurology, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria (UC), Santander, Spain.
75
CIBERNED, Centro de Investigación Biomédica en red Enfermedades Neurodegenerativas, Madrid, Spain.
76
Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
77
Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany.
78
Department of Psychiatry and Psychotherapy, HELIOS Hospital Stralsund, Stralsund, Germany.
79
Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, D-37075, Göttingen, Germany.
80
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
81
Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.
82
Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
83
University Clinic for Child and Adolescent Psychiatry (UCCAP), University of Zurich, Zurich, Switzerland.
84
Wellcome Trust Centre for Neuroimaging, University College London, London, UK.
85
UCL Max Planck Centre for Computational Psychiatry and Ageing, University College London, London, UK.
86
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
87
Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
88
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 Wan Ping Nan Road, Shanghai, 200030, China.
89
De Bascule, Academic Center for Child and Adolescent Psychiatry, Amsterdam, The Netherlands.
90
AMC, department of child and adolescent psychiatry, Amsterdam, The Netherlands.
91
Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.
92
NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine. Psychiatry section, University of Oslo, Oslo, Norway.
93
Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
94
Imaging Genetics Center, Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Los Angeles, 90292, USA.
95
Department of Clinical Radiology, University of Münster, Münster, Germany.
96
Department of Psychiatry & Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea.
97
Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
98
Department of Brain & Cognitive Sciences, College of Natural Science, Seoul National University, Seoul, Republic of Korea.
99
Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
100
Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands.
101
Department of Psychiatry, University of Stellenbosch and MRC Unit on Anxiety & Stress Disorders, Tygerberg, Cape Town, South Africa.
102
Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, UK.
103
QIMR Berghofer Medical Research Institute, Brisbane, Australia.
104
Department of Psychiatry, Bellvitge University Hospital - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.
105
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes - Sorbonne Paris Cité, and Maison de Solenn, Paris, France.
106
Maison de Solenn, Paris, France.
107
Department of Clinical Neuroscience,Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden.
108
Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
109
CIBER Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.
110
Department of Clinical Sciences, University of Barcelona, Barcelona, Spain.
111
UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, UT Houston Medical School, Houston, TX, USA.
112
Department of Neural Computation for Decision-Making, ATR Brain Information Communication Research Laboratory Group, Kyoto, Japan.
113
Department of Neuropsychiatry, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
114
Center for Neurobehavioral Genetics, University of California, Los Angeles, USA.
115
AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, Paris, France.
116
Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany.
117
Rotman Research Institute, Baycrest and Departments of Psychology and Psychiatry, University of Toronto, M6A 2E1, Toronto, ON, Canada.
118
Department of Child and Adolescent Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
119
Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
120
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, 77054, USA.
121
Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Barcelona, Spain.
122
Department of Psychiatry, University of Cape Town and MRC Unit on Anxiety & Stress Disorders, Cape Town, South Africa.
123
Queensland Brain Institute, The University of Queensland, Brisbane, Australia.
124
Laboratory of Human Genetics and Cognitive Functions, Institut Pasteur, 75015, Paris, France.
125
Department of Psychology, Georgia State University, Atlanta, GA, USA.
126
Department of Neuroscience, Georgia State University, Atlanta, GA, USA.
127
Department of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa.
128
Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
129
Department of Psychology, University College Dublin, Dublin, Ireland.
130
German Center for Neurodegenerative Diseases (DZNE), Site Rostock, Greifswald, Germany.
131
Queensland Brain Institute and Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia.
132
Seoul National University Hospital, Seoul, Republic of Korea.
133
Cognitive Genetics and Therapy Group, School of Psychology & Discipline of Biochemistry, National University of Ireland Galway, Galway, SW4 794, Ireland.
134
School of Psychology, Shaanxi Normal University, Xi'an, China.
135
Department of Psychiatry, Yale University, New Haven, CT, 06511, USA.
136
Olin Neuropsychiatric Research Center, Hartford, CT, 06114, USA.
137
Language & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. clyde.francks@mpi.nl.
138
Donders Institute for Brain, Cognition and Behaviour, Raboud University, Nijmegen, The Netherlands. clyde.francks@mpi.nl.

Abstract

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.

KEYWORDS:

Age; Enigma; Handedness; Heritability; Meta-analysis; Sex; Subcortical brain asymmetry

PMID:
27738994
PMCID:
PMC5540813
[Available on 2018-04-13]
DOI:
10.1007/s11682-016-9629-z
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for HAL archives ouvertes
    Loading ...
    Support Center