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EJNMMI Res. 2016 Dec;6(1):68. doi: 10.1186/s13550-016-0215-6. Epub 2016 Aug 1.

Quantification of myocardial blood flow with (82)Rb: Validation with (15)O-water using time-of-flight and point-spread-function modeling.

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Biomedical Engineering, Yale University, New Haven, CT, USA.
PET Center, Yale School of Medicine, PO Box 208048, New Haven, CT, 06520-8048, USA.
PET Center, Diagnostic Radiology, School of Medicine, Yale University, New Haven, CT, USA.
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University, New Haven, CT, USA.
Biomedical Engineering, Yale University, New Haven, CT, USA.



We quantified myocardial blood flow with (82)Rb PET using parameters of the generalized Renkin-Crone model estimated from (82)Rb and (15)O-water images reconstructed with time-of-flight and point spread function modeling. Previous estimates of rubidium extraction have used older-generation scanners without time-of-flight or point spread function modeling. We validated image-derived input functions with continuously collected arterial samples.


Nine healthy subjects were scanned at rest and under pharmacological stress on the Siemens Biograph mCT with (82)Rb and (15)O-water PET, undergoing arterial blood sampling with each scan. Image-derived input functions were estimated from the left ventricle cavity and corrected with tracer-specific population-based scale factors determined from arterial data. Kinetic parametric images were generated from the dynamic PET images by fitting the one-tissue compartment model to each voxel's time activity curve. Mean myocardial blood flow was determined from each subject's (15)O-water k 2 images. The parameters of the generalized Renkin-Crone model were estimated from these water-based flows and mean myocardial (82)Rb K 1 estimates.


Image-derived input functions showed improved agreement with arterial measurements after a scale correction. The Renkin-Crone model fit (a = 0.77, b = 0.39) was similar to those previously published, though b was lower.


We have presented parameter estimates for the generalized Renkin-Crone model of extraction for (82)Rb PET using human (82)Rb and (15)O-water PET from high-resolution images using a state-of-the-art time-of-flight-capable scanner. These results provide a state-of-the-art methodology for myocardial blood flow measurement with (82)Rb PET.


Image-derived input function; Myocardial blood flow; Rubidium-82 PET; TOF PET

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