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Surg Neurol Int. 2016 Aug 26;7:78. doi: 10.4103/2152-7806.189296. eCollection 2016.

Traumatic brain injury and subsequent glioblastoma development: Review of the literature and case reports.

Author information

1
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA.
2
Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA.
3
Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA; Kimmel Center for Stem Cell Biology, NYU School of Medicine, Brooklyn, New York, USA.
4
Division of Neurosurgery, Maimonides Medical Center, Brooklyn, New York, USA.
5
Department of Radiation Oncology, NYU School of Medicine, Brooklyn, New York, USA; Maimonides Cancer Center, Brooklyn, New York, USA.
6
Department of Radiology, NYU School of Medicine, Brooklyn, New York, USA.
7
Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA; Kimmel Center for Stem Cell Biology, NYU School of Medicine, Brooklyn, New York, USA; Brain Tumor Center, NYU School of Medicine, Brooklyn, New York, USA.

Abstract

BACKGROUND:

Previous reports have proposed an association between traumatic brain injury (TBI) and subsequent glioblastoma (GBM) formation.

METHODS:

We used literature searches and radiographic evidence from two patients to assess the possibility of a link between TBI and GBM.

RESULTS:

Epidemiological studies are equivocal on a possible link between brain trauma and increased risk of malignant glioma formation. We present two case reports of patients with GBM arising at the site of prior brain injury.

CONCLUSION:

The hypothesis that TBI may predispose to gliomagenesis is disputed by several large-scale epidemiological studies, but supported by some. Radiographic evidence from two cases presented here suggest that GBM formed at the site of brain injury. We propose a putative pathogenesis model that connects post-traumatic inflammation, stem and progenitor cell transformation, and gliomagenesis.

KEYWORDS:

Brain tumor; glioblastoma; traumatic brain injury

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