Format

Send to

Choose Destination
Pigment Cell Melanoma Res. 2016 Nov;29(6):627-642. doi: 10.1111/pcmr.12538. Epub 2016 Oct 22.

Melanoma central nervous system metastases: current approaches, challenges, and opportunities.

Author information

1
Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
2
Department of Melanoma, Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
3
Department of Medical Oncology & Therapeutics Research, City of Hope Cancer Center, Duarte, CA, USA.
4
Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
5
Division of Neuro-Oncology, Massachusetts General Hospital, Boston, MA, USA.
6
Division of Neuro-Oncology, MD Anderson Cancer Center, Houston, TX, USA.
7
Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA.
8
Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
9
Department of Neurology & Herbert Irving Comprehensive, Cancer Center, Columbia University Medical Center, New York, NY, USA.
10
UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
11
Department of Oncology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.
12
Division of Neuro-Oncology, Department of Neurology, Stanford University, Stanford, CA, USA.
13
Department of Radiology, New York-Presbyterian Hospital - Weill Cornell Medicine, New York, NY, USA.
14
Department of Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
15
Department of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.
16
Melanoma Research Foundation, Washington, DC, USA.

Abstract

Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here, we provide a review of the current status of the field of melanoma brain metastasis research; identify key challenges and opportunities for improving the outcomes in patients with melanoma brain metastases; and set a framework to optimize future research in this critical area.

KEYWORDS:

brain metastasis; clinical trials; experimental models; leptomeningeal disease; tumor microenvironment

PMID:
27615400
PMCID:
PMC5398760
DOI:
10.1111/pcmr.12538
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center