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Immunity. 2016 Sep 20;45(3):583-596. doi: 10.1016/j.immuni.2016.08.002. Epub 2016 Aug 23.

CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha.

Author information

1
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
2
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
3
Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
4
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA.
5
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA. Electronic address: akiko.iwasaki@yale.edu.

Abstract

Mononuclear phagocytes (MNPs) are a highly heterogeneous group of cells that play important roles in maintaining the body's homeostasis. Here, we found CD301b (also known as MGL2), a lectin commonly used as a marker for alternatively activated macrophages, was selectively expressed by a subset of CD11b(+)CD11c(+)MHCII(+) MNPs in multiple organs including adipose tissues. Depleting CD301b(+) MNPs in vivo led to a significant weight loss with increased insulin sensitivity and a marked reduction in serum Resistin-like molecule (RELM) α, a multifunctional cytokine produced by MNPs. Reconstituting RELMα in CD301b(+) MNP-depleted animals restored body weight and normoglycemia. Thus, CD301b(+) MNPs play crucial roles in maintaining glucose metabolism and net energy balance.

KEYWORDS:

adipose tissue macrophage; alternatively activated macrophage; glucose metabolism

PMID:
27566941
PMCID:
PMC5033704
DOI:
10.1016/j.immuni.2016.08.002
[Indexed for MEDLINE]
Free PMC Article

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