Impact of Maspin Polymorphism rs2289520 G/C and Its Interaction with Gene to Gene, Alcohol Consumption Increase Susceptibility to Oral Cancer Occurrence

PLoS One. 2016 Aug 15;11(8):e0160841. doi: 10.1371/journal.pone.0160841. eCollection 2016.

Abstract

Background: The purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status.

Methodology/principal findings: Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR. The participants with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 polymorphism had a 2.07-fold (p = 0.01) and a 2.01-fold (p = 0.02) risk of developing oral cancer compared to those with C/C homozygotes. Moreover, gene-gene interaction increased the risk of oral cancer susceptibility among subjects expose to oral cancer related risk factors, including areca, alcohol, and tobacco consumption.

Conclusion: G allele of Maspin rs2289520 polymorphism may be a factor that increases the susceptibility to oral cancer. The interactions of gene to oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.

MeSH terms

  • Alcohol Drinking / adverse effects*
  • Case-Control Studies
  • Epistasis, Genetic*
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms / genetics*
  • Mouth Neoplasms / pathology
  • Polymorphism, Single Nucleotide*
  • Serpins / genetics*

Substances

  • SERPIN-B5
  • Serpins

Grants and funding

This study was financially supported by grants from Ministry of Science and Technology, Taiwan (MOST 102-2314-B-040-002) & (MOST 103-2314-B-040-005-MY3). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.