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Physiology (Bethesda). 2016 Sep;31(5):359-69. doi: 10.1152/physiol.00007.2016.

Ion Channels in Endothelial Responses to Fluid Shear Stress.

Author information

1
Department of Internal Medicine (Cardiology), Yale Cardiovascular Research Center, Yale University, New Haven, Connecticut; and.
2
Department of Internal Medicine (Cardiology), Yale Cardiovascular Research Center, Yale University, New Haven, Connecticut; and Departments of Cell Biology and Biomedical Engineering, Yale University, New Haven, Connecticut martin.schwartz@yale.edu.

Abstract

Fluid shear stress is an important environmental cue that governs vascular physiology and pathology, but the molecular mechanisms that mediate endothelial responses to flow are only partially understood. Gating of ion channels by flow is one mechanism that may underlie many of the known responses. Here, we review the literature on endothelial ion channels whose activity is modulated by flow with an eye toward identifying important questions for future research.

PMID:
27511462
PMCID:
PMC5504459
DOI:
10.1152/physiol.00007.2016
[Indexed for MEDLINE]
Free PMC Article

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