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Curr Opin Cell Biol. 2016 Dec;43:30-37. doi: 10.1016/j.ceb.2016.07.004. Epub 2016 Jul 27.

Live imaging of stem cells: answering old questions and raising new ones.

Author information

1
Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.
2
Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Departments of Dermatology & Cell Biology, Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: valentina.greco@yale.edu.
3
Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: katherine.cockburn@yale.edu.

Abstract

Stem cells are essential for both tissue maintenance and injury repair, but many aspects of stem cell biology remain incompletely understood. Recent advances in live imaging technology have allowed the direct visualization and tracking of a wide variety of tissue-resident stem cells in their native environments over time. Results from these studies have helped to resolve long-standing debates about stem cell regulation and function while also revealing previously unanticipated phenomena that raise new questions for future work. Here we review recent discoveries of both types, with a particular emphasis on how stem cells behave and interact with their niches during homeostasis, as well as how these behaviours change in response to wounding.

PMID:
27474806
PMCID:
PMC5154884
DOI:
10.1016/j.ceb.2016.07.004
[Indexed for MEDLINE]
Free PMC Article

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