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Diagn Microbiol Infect Dis. 2016 Sep;86(1):93-6. doi: 10.1016/j.diagmicrobio.2016.06.015. Epub 2016 Jun 22.

Insights into Borrelia miyamotoi infection from an untreated case demonstrating relapsing fever, monocytosis and a positive C6 Lyme serology.

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Division of Infectious Diseases, New York Medical College, Valhalla, NY, 10595, USA.
Department of Pathology, New York Medical College, Valhalla, NY, 10595, USA; Department of Pathology and Clinical Laboratories, Westchester Medical Center, Valhalla, NY, 10595, USA.
Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Yale School of Public Health and Yale School of Medicine, Yale University, New Haven, CT, USA.
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Division of Infectious Diseases, New York Medical College, Valhalla, NY, 10595, USA. Electronic address:


We describe a patient from the United States with PCR- and serology-confirmed Borrelia miyamotoi infection who recovered without antibiotics. Our findings suggest that B. miyamotoi infection may cause relapsing fever, blood monocytosis and antibody reactivity to the C6 peptide. Further studies are required to better define the spectrum of clinical and laboratory findings for this emerging tick-transmitted infection.


Borrelia; Borrelia Miyamotoi; C6 serology; Lyme disease; Monocytosis; Relapsing fever

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