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Curr Biol. 2016 Jul 11;26(13):R539-R542. doi: 10.1016/j.cub.2016.05.032.

Protein Modification: Bacterial Effectors Rewrite the Rules of Ubiquitylation.

Author information

1
Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520, USA.
2
Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520, USA. Electronic address: mark.hochstrasser@yale.edu.

Abstract

A family of virulence factors from the bacterial pathogen Legionella pneumophila has been discovered to modify human Rab GTPases with ubiquitin. Surprisingly, this modification occurs via a non-canonical mechanism that uses nicotinamide adenine dinucleotide as a cofactor.

PMID:
27404243
DOI:
10.1016/j.cub.2016.05.032
[Indexed for MEDLINE]
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