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J Am Chem Soc. 2016 Jul 20;138(28):8718-21. doi: 10.1021/jacs.6b05271. Epub 2016 Jul 12.

Intermolecular Hydropyridylation of Unactivated Alkenes.

Author information

1
Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.
2
Department of Pharmacology, Yale School of Medicine , New Haven, Connecticut 06520, United States.

Abstract

A general method for the hydropyridylation of unactivated alkenes is described. The transformation connects metal-mediated hydrogen atom transfer to alkenes and Minisci addition reactions. The reaction proceeds under mild conditions with high site-selectivities and allows for the construction of tertiary and quaternary centers from simple alkene starting materials.

PMID:
27384921
DOI:
10.1021/jacs.6b05271

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