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Gac Med Mex. 2016 May-Jun;152(3):329-33.

[Association between the feeding behavior factors and the expression of DRD2 gene: a study of mexican monozygotic twins].

[Article in Spanish]

Author information

1
Hospital Infantil Juan N. Navarro, Secretaría de Salud, Ciudad de México, México.
2
Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, México.
3
Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Comalcalco, Comalcalco, Villahermosa, Tab., México.
4
Hospital General de Yajalón, Secretaría de Salud, Yajalón, Tuxtla Gutiérrez, Chis., México.
5
Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Jalpa de Méndez, Cunduacán, Villahermosa, Tab., México.

Abstract

INTRODUCTION:

The feeding behavior in humans is complex, with psychological, social, and cultural factors. This pathology consists of the desire to eat (reinforcement/reward) and the control of the act of eating (inhibitory control). It is well known that blocking post-synaptic D2 receptors in the nucleus accumbens induces a decrease of craving behavior. Due to this, to test hypothesis we measured the expression of the DRD2 gene and the expression of the type of feeding factor in a group of Mexican twins.

METHODS:

In the study were included 18 pairs of twins (n = 36), reared together (at least up to 18 years old); native to Mexico City; to whom we applied the three factors of food instrument.

RESULTS:

We observed a significant correlation between the "uncontrolled" factor and expression of the DRD2 gene (p < 0.03).

CONCLUSION:

Therefore, we propose that the expression of the DRD2 gene in subjects is a linkage to the type of feeding factor.

PMID:
27335187
[Indexed for MEDLINE]
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