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Gac Med Mex. 2016 May-Jun;152(3):329-33.

[Association between the feeding behavior factors and the expression of DRD2 gene: a study of mexican monozygotic twins].

[Article in Spanish]

Author information

Hospital Infantil Juan N. Navarro, Secretaría de Salud, Ciudad de México, México.
Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, México.
Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Comalcalco, Comalcalco, Villahermosa, Tab., México.
Hospital General de Yajalón, Secretaría de Salud, Yajalón, Tuxtla Gutiérrez, Chis., México.
Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Jalpa de Méndez, Cunduacán, Villahermosa, Tab., México.



The feeding behavior in humans is complex, with psychological, social, and cultural factors. This pathology consists of the desire to eat (reinforcement/reward) and the control of the act of eating (inhibitory control). It is well known that blocking post-synaptic D2 receptors in the nucleus accumbens induces a decrease of craving behavior. Due to this, to test hypothesis we measured the expression of the DRD2 gene and the expression of the type of feeding factor in a group of Mexican twins.


In the study were included 18 pairs of twins (n = 36), reared together (at least up to 18 years old); native to Mexico City; to whom we applied the three factors of food instrument.


We observed a significant correlation between the "uncontrolled" factor and expression of the DRD2 gene (p < 0.03).


Therefore, we propose that the expression of the DRD2 gene in subjects is a linkage to the type of feeding factor.

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