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Version 2. F1000Res. 2016 Mar 15 [revised 2016 Jun 2];5:353. doi: 10.12688/f1000research.8300.2. eCollection 2016.

Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction.

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National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Icahn School of Medicine and James J. Peters VAMC, New York, NY, USA.
Yale University School of Medicine, New Haven, CT, USA.
Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Berenson-Allen Center for Noninvasive Brain Stimulation and Division for Cognitive Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.


Scientific evidence has established several links between metabolic and neurocognitive dysfunction, and epidemiologic evidence has revealed an increased risk of Alzheimer's disease and vascular dementia in patients with diabetes. In July 2015, the National Institute of Diabetes, Digestive, and Kidney Diseases gathered experts from multiple clinical and scientific disciplines, in a workshop entitled "The Intersection of Metabolic and Neurocognitive Dysfunction", to clarify the state-of-the-science on the mechanisms linking metabolic dysfunction, and insulin resistance and diabetes in particular, to neurocognitive impairment and dementia. This perspective is intended to serve as a summary of the opinions expressed at this meeting, which focused on identifying gaps and opportunities to advance research in this emerging area with important public health relevance.


Alzheimer’s disease; Diabetes; cognition; cognitive impairment; insulin resistance; mechanism; obesity; vascular dementia

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