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Cell Stem Cell. 2016 Jun 2;18(6):684-6. doi: 10.1016/j.stem.2016.05.006.

Fat Decisions: Leptin Regulates Bone versus Fat in the Marrow.

Author information

1
Department of Molecular, Cell and Developmental Biology, Yale University and the Section of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: matthew.rodeheffer@yale.edu.
2
Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT 06510, USA.

Abstract

Leptin is an adipocyte-derived hormone involved in energy sensing. In this issue of Cell Stem Cell, Yue et al. (2016) show that leptin is a physiologic signal that acts directly on Leptin-Receptor-expressing mesenchymal stromal cells in adult bone marrow to influence their lineage allocation in vivo, inhibiting bone formation and inducing marrow adipogenesis.

PMID:
27257753
DOI:
10.1016/j.stem.2016.05.006
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