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J Exp Pharmacol. 2012 Sep 5;4:113-23. doi: 10.2147/JEP.S27084. eCollection 2012.

The pharmacology and therapeutic potential of (-)-huperzine A.

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Department of Chemistry, Yale University, New Haven, CT, USA.


(-)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegenerative diseases, including Alzheimer's disease. In this review, we will discuss the pharmacology and therapeutic potential of (-)-huperzine A (1). Synthetic studies of (-)-huperzine A (1) aimed at enabling its development as a pharmaceutical will be described.


Alzheimer’s; NMDA; natural products; neurodegeneration; synthesis

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