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J Clin Lab Anal. 2016 Nov;30(6):1086-1091. doi: 10.1002/jcla.21985. Epub 2016 Apr 28.

Age-Adjusted Glycated Albumin at Diagnosis is more Correlated with the Product of Age and Plasma Glucose than Plasma Glucose Alone in Patients with Neonatal Diabetes Mellitus.

Author information

1
Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan.
2
Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan. shige5p@asahikawa-med.ac.jp.
3
Department of Pediatrics, Sapporo Tokushukai Hospital, Sapporo, Japan.
4
Department of Neonatology, Japanese Red Cross Medical Center, Tokyo, Japan.
5
Department of Pediatrics, Kochi Medical School, Kochi, Japan.
6
Department of Neonatology, Kameda Medical Center, Kamogawa, Japan.
7
Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan.
8
Department of Pediatrics, Yokkaichi Municipal Hospital, Yokkaichi, Japan.
9
Department of Pediatrics and Perinatology, Tottori University Faculty of Medicine, Tottori, Japan.
10
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
11
Department of Pediatrics, Surugadai Nihon University Hospital, Tokyo, Japan.
12
Department of Internal Medicine, Kawanishi City Hospital, Kawanishi, Japan.

Abstract

BACKGROUND:

We previously showed that glycated albumin (GA) is a useful glycemic control indicator in patients with neonatal diabetes mellitus (NDM), and that age-adjusted GA (Aa-GA) can reflect more accurately glycemic control status. Here, we investigated whether the age at diagnosis influences Aa-GA at diagnosis of NDM.

METHODS:

Eight patients with NDM whose GA was measured at diagnosis (age at diagnosis: 39 ± 18 days; GA: 31.3 ± 7.6%; Aa-GA: 47.1 ± 10.3%; plasma glucose: 525 ± 194 mg/dl) were included. Aa-GA was calculated as follows: Aa-GA = GA × 14.0/[1.77 × log-age (days) + 6.65]. Correlations of GA or Aa-GA at diagnosis with its logarithmically transformed age in days (log-age), plasma glucose, and their product were investigated.

RESULTS:

GA at diagnosis was not significantly correlated with log-age or plasma glucose. On the other hand, Aa-GA at diagnosis was significantly positively correlated with plasma glucose (R = 0.75, P = 0.031) and was more strongly positively correlated with the product of plasma glucose and log-age (R = 0.82, P = 0.012) although it was not correlated with log-age.

CONCLUSION:

Aa-GA at diagnosis is influenced by both age in days and plasma glucose. This finding is likely to show the aspect that age in days is almost equal to diabetes duration because glycemic control indicators including GA reflect the weighted mean of plasma glucose.

KEYWORDS:

diabetes duration; glycated albumin; neonatal diabetes mellitus; plasma glucose

PMID:
27121214
DOI:
10.1002/jcla.21985
[Indexed for MEDLINE]

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