Format

Send to

Choose Destination
J Thorac Oncol. 2016 Jul;11(7):964-75. doi: 10.1016/j.jtho.2016.04.014. Epub 2016 Apr 23.

PD-L1 Expression in Lung Cancer.

Author information

1
Department of Medicine/Medical Oncology, University of Colorado Cancer Center, University of Colorado, Denver, Colorado.
2
Department of Medicine/Medical Oncology, University of Colorado Cancer Center, University of Colorado, Denver, Colorado; Department of Pathology, University of Colorado, Denver, Colorado; Department of Pathology, Moffitt Cancer Center, Tampa, Florida; Department of Thoracic Oncology, Moffitt Cancer Center, Tampa, Florida.
3
Department of Oncology, Shanghai Pulmonary Hospital, Shanghai, People's Republic of China.
4
Department of Pathology, Yale University, New Haven, Connecticut.
5
Department of Medicine/Medical Oncology, University of Colorado Cancer Center, University of Colorado, Denver, Colorado; Department of Pathology, University of Colorado, Denver, Colorado. Electronic address: Fred.Hirsch@ucdenver.edu.

Erratum in

Abstract

Immunotherapies targeted against programmed death ligand 1 (PD-L1) and its receptor (PD-1) have improved survival in a subset of patients with advanced lung cancer. PD-L1 protein expression has emerged as a biomarker that predicts which patients are more likely to respond to immunotherapy. The understanding of PD-L1 as a biomarker is complicated by the history of use of different immunohistochemistry platforms with different PD-L1 antibodies, scoring systems, and positivity cut-offs for immunotherapy clinical trials with different anti-PD-L1 and anti-PD-1 drugs. Herein, we summarize the brief history of PD-L1 as a biomarker and describe the challenges remaining to harmonize PD-L1 detection and interpretation for best patient care.

KEYWORDS:

Biomarker; Immunotherapy; Lung cancer; PD-L1

PMID:
27117833
PMCID:
PMC5353357
DOI:
10.1016/j.jtho.2016.04.014
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center