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PLoS One. 2016 Apr 8;11(4):e0150806. doi: 10.1371/journal.pone.0150806. eCollection 2016.

National Assessment of Statin Therapy in Patients Hospitalized with Acute Myocardial Infarction: Insight from China PEACE-Retrospective AMI Study, 2001, 2006, 2011.

Collaborators (372)

Weng S, Xie S, Wu L, Chen J, Li T, Wang J, Yu Q, Li X, Li Z, Hao S, Zhang Y, Wu X, Zhang Y, Liu Z, Wang Z, Jia H, Bate B, Qiqige B, Jin X, Cai T, Liu F, Xu D, He X, Yang S, Yuan C, Wang J, Gu L, Li L, Chen S, Zhi Y, Sun L, Zhou S, Jin L, Leng Y, Zhang L, Deng T, Wang Y, Zhang W, Ma X, Li W, Lu L, Ge X, Wu X, He Y, Meng F, Li J, Liao D, Liu G, Long W, Chen X, Zhang B, Yin Y, Tian B, Yi Y, Wu C, Liu B, Zhao Z, Li H, Guo Y, Chen X, Xiang L, Ning L, Chen M, Jin X, Li G, Li X, Wu X, Tan C, Feng M, Wang M, Wen L, Fu X, Xie Q, Zhang W, Zhuang Y, Lu H, Lu J, Huang Y, Zhou Y, Hu Q, Xiao C, Hu X, Wu Y, Wang Q, Xu Y, Yu X, Gao C, Zhang J, Zhang Y, Niu W, Ma X, Wang Y, Pan X, Liu Y, HospitalFirst HX, Miao L, Yin Y, Zhang Z, Feng S, Wang A, Zhang J, Li F, Wang H, Yu L, Zhao X, Shen Y, Li Z, He L, Rong Z, Luo W, Wang X, Wan R, Tang J, Wu G, Wu J, Xu B, Huang Q, Wu X, Ge S, Pu P, Duoji P, Dai H, Du Y, Guo W, Shi J, Zhao P, Sun J, Li H, Liang W, Qin W, Dong Z, Zhao Z, Li X, Xu Q, Yuan Y, Li Z, Gao J, Guo Q, Zhao R, Song G, Wang L, Song H, Bai L, He J, He J, Shang K, Liu C, Xi K, Liu R, Guo P, Guo C, Liu X, Zhao R, Yu Z, Li W, Jing X, Wang H, Zhao X, Zhang C, Chen L, Wei M, Liu Y, Chen S, Chen K, Fang Y, Liao Y, Wang J, Liu T, Cheng S, Zhou Y, Niu X, Cao H, Feng Z, Feng M, Duan F, Yi H, Xu Y, Guo A, Zhou X, Cai H, Zheng P, Guo G, Li X, Bao M, Liu Y, Chen S, Jia H, Peng H, Dai D, Hong S, Chen S, Zhang D, Wang Y, Li Y, Gao J, Yang S, An J, Shen C, Liu Y, Wu C, Qu H, Chen S, Lin Y, Jiao D, Wang M, Wang Q, Xue Y, Zhang R, Yuan C, Wu L, Zhang J, Wei C, Shen Y, Zhang H, Pan H, Gao Y, Ma X, Liang Y, Wang T, Zhao D, Tu X, Gao Z, Wang F, Yang Q, Kang X, Fang J, Liu D, Shen C, Li M, Guan Y, Wang W, Xiao T, Wang Q, Jiang F, Wu K, Wang S, Fu X, Zhang S, Lifang Gao, Zhang M, Fu K, Duan X, Xiao R, Wu R, Li B, Zhang H, Ma Y, Cao Z, Ba Z, Fu W, Jiang J, Mi Y, Zhou W, Feng Sun, Zhang Q, Zheng S, Zhang J, Zhong Y, Li F, Wang X, Dong P, Du L, Liu W, He Z, Jin M, Jiang T, Chen Z, Cheng M, Ji Y, Zhou Y, Li J, Pan Y, Liu J, Wang T, Yang P, Huang G, Pan J, Cai Q, Wang Q, Lv M, Yi Y, Deng X, Chen W, Cai R, Zhang B, Yu B, Xu Y, Wang Z, Shu J, Zhang G, Li K, Ma G, Suo P, Zhang A, Kang Y, Wan Z, Sun Y, Bian B, Hu X, Ciren D, Jia G, Pan J, Li G, Zhang H, Zhan L, Fang J, Yu X, Wang D, Liu D, Cao X, Tian Y, Zhu H, Liu W, Zhou Z, Shi L, Fang W, Chen M, Han F, Fu J, Wang Y, Liu B, Zhang Y, Yuan X, Lin Q, Chen Y, Zhu Y, Cai Z, Li X, Ao L, Wu S, Zhang H, Zhao F, Yang G, Liu R, Ai W, Chang J, Zhao H, Ran Q, Ma X, Jiang S, Shu X, Peng Z, Han Y, Wang J, Yang L, Shen Y, Shang X, Wang H, Li H, Liao Z, Cao Y, Gao X, Cai M, You L, Li X, Li S, Li Y, Yang J, Ai S, Ma J, Deng L, Wang K, Gao S, Guan J, He B, Lu Y, Yang W, Li H, Zhang Z, Chi X, Duan R, Wang G.

Author information

National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Center for Healthcare Advancement & Outcomes, Baptist Health South Florida, Miami, Florida, United States of America.
Miami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, United States of America.
The Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut, United States of America.
Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
Saint Luke's Mid America Heart Institute, University of Missouri Kansas City, Kansas City, Missouri, United States of America.
Section of Cardiovascular Medicine and the Robert Wood Johnson Clinical Scholars Program, Department of Internal Medicine, Yale University School of Medicine, New Haven, United States of America.
Department of Health Policy and Management, Yale School of Public Health, New Haven, United States of America.



Statin therapy is among the most effective treatments to improve short- and long-term mortality after acute myocardial infarction. The use of statin, and the intensity of their use, has not been described in acute myocardial infarction patients in China, a country with a rapidly growing burden of cardiovascular disease.


Using a nationally representative sample of patients with acute myocardial infarction admitted to 162 Chinese hospitals in 2001, 2006 and 2011, we identified 14,958 patients eligible for statin therapy to determine rates of statin use and the intensity of statin therapy, defined as those statin regimens with expected low-density lipoprotein cholesterol lowering of at least 40%, to identify factors associated with the use of statin therapy. Statin use among hospitalized patients with acute myocardial infarction increased from 27.9% in 2001 to 72.5% in 2006, and 88.8% in 2011 (P<0.001 for trend). Regional variation in statin use correspondingly decreased over time. Among treated patients, those receiving intensive statin therapy increased from 1.0% in 2001 to 24.2% in 2006 to 57.2% in 2011(P<0.001 for trend). Patients without low-density lipoprotein cholesterol measured were less likely to be treated with statin or to receive intensive therapy.


The use of statin therapy has dramatically increased over the past decade in Chinese patients with acute myocardial infarction. However, half of patients still did not receive intensive statin therapy in 2011.Given that guidelines strongly endorse intensive statin therapy for acute myocardial infarction patients, initiatives promoting the use of statin therapy, with attention to treatment intensity, would support further improvements in practice.

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