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Curr Opin Cell Biol. 2016 Aug;41:9-17. doi: 10.1016/j.ceb.2016.03.009. Epub 2016 Mar 28.

A model for coordinating nuclear mechanics and membrane remodeling to support nuclear integrity.

Author information

1
Department of Cell Biology, Yale School of Medicine, New Haven, CT, United States. Electronic address: megan.king@yale.edu.
2
Department of Cell Biology, Yale School of Medicine, New Haven, CT, United States. Electronic address: patrick.lusk@yale.edu.

Abstract

A polymer network of intranuclear lamin filaments underlies the nuclear envelope and provides mechanical stability to the nucleus in metazoans. Recent work demonstrates that the expression of A-type lamins scales positively with the stiffness of the cellular environment, thereby coupling nuclear and extracellular mechanics. Using the spectrin-actin network at the erythrocyte plasma membrane as a model, we contemplate how the relative stiffness of the nuclear scaffold impinges on the growing number of interphase-specific nuclear envelope remodeling events, including recently discovered, nuclear envelope-specialized quality control mechanisms. We suggest that a stiffer lamina impedes these remodeling events, necessitating local lamina remodeling and/or concomitant scaling of the efficacy of membrane-remodeling machineries that act at the nuclear envelope.

PMID:
27031045
PMCID:
PMC5057576
DOI:
10.1016/j.ceb.2016.03.009
[Indexed for MEDLINE]
Free PMC Article

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