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Dev Med Child Neurol. 2016 Mar;58 Suppl 4:28-34. doi: 10.1111/dmcn.13043.

Functional magnetic resonance connectivity studies in infants born preterm: suggestions of proximate and long-lasting changes in language organization.

Author information

  • 1Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
  • 2Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA.
  • 3Warren Alpert Brown Medical School, Providence, RI, USA.
  • 4Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA.
  • 5Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.
  • 6Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.

Abstract

Sophisticated neuroimaging strategies demonstrate alterations in functional connectivity at school age, adolescence, and young adulthood in individuals born preterm. Recent data suggest these alterations are present in the postnatal period prior to term-equivalent age in neonates born preterm. Likewise, functional organization increases across development, but the influence of preterm birth on this fundamental infrastructure is immediate and unchanging. This article briefly reviews the current methods of measuring functional connectivity throughout development in those born preterm, and the association of functional connectivity with language disorders. Taken together, these data suggest that the effects of preterm birth on the functional organization of language in the developing brain are both proximate and long-lasting.

PMID:
27027605
DOI:
10.1111/dmcn.13043
[PubMed - indexed for MEDLINE]
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