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Asia Pac Psychiatry. 2016 Dec;8(4):309-311. doi: 10.1111/appy.12240. Epub 2016 Mar 25.

The symptom trajectories to clinical remission in Chinese patients with unipolar major depressive disorder.

Author information

1
Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
2
Department of Psychiatry, Shenzhen Sixth Hospital, Shenzhen, China.
3
Department of Psychosomatics, Hunan Mental Hospital, Changsha, Hunan, China.
4
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
5
Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. zhangyl69@vip.sina.com.
6
Beijing Huilongguan Hospital, Beijing, China.

Abstract

There is little understanding of how unipolar major depressive disorder (UMDD) symptoms evolve in response to antidepressant treatment. The present research examined the associations between symptom trajectories and clinical remission in Chinese patients with UMDD. A total of 165 outpatients with UMDD received treatment of fluoxetine (20 mg/day) for 6 weeks and were assessed for symptom severity at weeks 1, 2, 4, and 6. We found that patients with UMDD show heterogeneity in treatment response to fluoxetine. Psychomotor retardation is a prominent symptom during the 6 weeks of assessment, and its severity at baseline is negatively associated with clinical remission.

KEYWORDS:

clinical remission; symptom; trajectory; unipolar major depressive disorder

PMID:
27015764
PMCID:
PMC5035708
DOI:
10.1111/appy.12240
[Indexed for MEDLINE]
Free PMC Article

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