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Psychiatr Genet. 2016 Jun;26(3):109-16. doi: 10.1097/YPG.0000000000000129.

Long noncoding RNAs in psychiatric disorders.

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Departments of aPsychiatry bCellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut cDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, Tennessee dDepartment of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, Texas eDepartment of Psychology, Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Neveda, USA fBiological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.


Long noncoding RNAs (lncRNAs) are nonprotein coding transcripts longer than 200 nucleotides. Many of these lncRNAs have regulatory functions and have recently emerged as major players in governing fundamental biological processes. Here, we review the definition, distribution, identification, databases, analysis, classification, and functions of lncRNAs. We also discuss the potential roles of lncRNAs in the etiological processes of psychiatric disorders and the implications for clinical diagnosis and treatment.

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