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Cancer Invest. 2016;34(3):155-66. doi: 10.3109/07357907.2016.1139717. Epub 2016 Mar 10.

Probenecid Sensitizes Neuroblastoma Cancer Stem Cells to Cisplatin.

Author information

1
a Functional Genomics Laboratory , Instituto Nacional de Medicina Genomica , Mexico City 14610 , Mexico.
2
b Department of Neurophysiology , Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez , Mexico City , Mexico.

Abstract

We used both in vitro cultures of neuroblastoma cell lines and nude-mice xenotransplants to explore the effects of co-administration of cisplatin and probenecid. Probenecid sensitized neuroblastoma cells, including tumor cells with stem features, to the effects of cisplatin, both in vitro and in vivo. This effect was mediated by an increase in the apoptotic cell death and a concomitant decrease in cell proliferation. This effect is accompanied by modulation of the mRNA and protein of the drug efflux transporters MDR1, MRP2, and BCRP. The co-administration of probenecid with cisplatin should be explored as a possible therapeutic strategy.

KEYWORDS:

Chemotherapy; Efficacy

PMID:
26963048
DOI:
10.3109/07357907.2016.1139717
[Indexed for MEDLINE]

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