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Diabetologia. 2016 May;59(5):933-7. doi: 10.1007/s00125-016-3909-4. Epub 2016 Mar 10.

Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis.

Author information

1
Department of Internal Medicine, Yale University School of Medicine, TAC, Room S269, PO Box 208020, New Haven, CT, 06519, USA.
2
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
3
Department of Internal Medicine, Yale University School of Medicine, TAC, Room S269, PO Box 208020, New Haven, CT, 06519, USA. gerald.shulman@yale.edu.
4
Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA. gerald.shulman@yale.edu.
5
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. gerald.shulman@yale.edu.
6
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. gerald.shulman@yale.edu.

Abstract

In this review we discuss the mechanisms for the pleotropic effects of leptin replacement therapy to reverse liver and muscle insulin resistance in lipodystrophic individuals, as well as insulin-independent effects of leptin replacement therapy to suppress white adipose tissue lipolysis, hepatic gluconeogenesis and fasting hyperglycaemia in rodent models of poorly controlled diabetes. On the basis of these studies we conclude with a view of the potential therapeutic applications of leptin replacement therapy in humans. This review summarises a presentation given at the 'Is leptin coming back?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Thomas Meek and Gregory Morton, DOI: 10.1007/s00125-016-3898-3 , and by Christoffer Clemmensen and colleagues, DOI: 10.1007/s00125-016-3906-7 ) and an overview by the Session Chair, Ulf Smith (DOI: 10.1007/s00125-016-3894-7 ).

KEYWORDS:

Diabetic ketoacidosis; Leptin; Lipodystrophy; Review; Type 1 diabetes

PMID:
26961503
PMCID:
PMC4826798
DOI:
10.1007/s00125-016-3909-4
[Indexed for MEDLINE]
Free PMC Article

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