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Mol Neurobiol. 2017 Apr;54(3):2234-2240. doi: 10.1007/s12035-016-9815-4. Epub 2016 Mar 3.

RIT2 Polymorphisms: Is There a Differential Association?

Author information

1
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
3
Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
4
Department of Medical Genetics, Faculty of Medicine, Tabriz University of medical Sciences, Tabriz, Iran.
5
Neurosciences Research Center, Tabriz University of medical Sciences, Tabriz, Iran.
6
Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
7
Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
8
Movement Disorders Clinic, Hazrat Rassol Hospital, Iran University of Medical Sciences, Tehran, Iran.
9
Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran.
10
Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
11
Department of Neurology, School of Medicine, Imam Khomeini Hospital and Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.
12
Sabzevar University of Medical Sciences, Sabzevar, Iran.
13
Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
14
Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
15
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
16
Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
17
Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran.
18
Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
19
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. darvish_mg@yahoo.com.

Abstract

Neurological disorders include a wide variety of mostly multifactorial diseases related to the development, survival, and function of the neuron cells. Single-nucleotide polymorphisms (SNPs) have been extensively studied in neurological disorders, and in a number of instances have been reproducibly linked to disease as risk factors. The RIT2 gene has been recently shown to be associated with a number of neurological disorders, such as Parkinson's disease (PD) and autism. In the study reported here, we investigated the association of the rs12456492 and rs16976358 SNPs of the RIT2 gene with PD, essential tremor (ET), autism, schizophrenia (SCZ), and bipolar disorder (BPD; total of 2290 patients), and 1000 controls, by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Significant association was observed between rs12456492 and two disorders, PD and ET, whereas rs16976358 was found to be associated with autism, SCZ, and BPD. Our findings are indicative of differential association between the RIT2 SNPs and different neurological disorders.

KEYWORDS:

Autism; Bipolar disorder; Essential tremor; Neurological disorders; Parkinson’s disease; Polymorphism; RIT2; Schizophrenia

PMID:
26941103
DOI:
10.1007/s12035-016-9815-4
[Indexed for MEDLINE]

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