Format

Send to

Choose Destination
Schizophr Res. 2016 Apr;172(1-3):68-74. doi: 10.1016/j.schres.2016.02.012. Epub 2016 Feb 15.

A network of synaptic genes associated with schizophrenia and bipolar disorder.

Author information

1
Applied Molecular Genomics Unit, Department of Molecular Genetics, VIB, Belgium; University of Antwerp, Antwerp, Belgium; Laboratory of Behavioral and Developmental Genetics, VIB, Belgium; Catholic University of Leuven, Leuven, Belgium; Laboratory of NeuroPsychiatric Genetics, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia.
2
Laboratory of Behavioral and Developmental Genetics, VIB, Belgium; Catholic University of Leuven, Leuven, Belgium.
3
Applied Molecular Genomics Unit, Department of Molecular Genetics, VIB, Belgium; University of Antwerp, Antwerp, Belgium.
4
Department of Clinical Sciences, Division of Psychiatry, University of Umeå, Umeå, Sweden; Sunderby Hospital, Sweden.
5
Department of Psychology, Stockholm University, Stockholm, Sweden.
6
Laboratory of Behavioral and Developmental Genetics, VIB, Belgium; Catholic University of Leuven, Leuven, Belgium. Electronic address: Patrick.Callaerts@cme.vib-kuleuven.be.
7
Applied Molecular Genomics Unit, Department of Molecular Genetics, VIB, Belgium; University of Antwerp, Antwerp, Belgium. Electronic address: jurgen.delfavero@molgen.vib-ua.be.

Abstract

Identification of novel candidate genes for schizophrenia (SZ) and bipolar disorder (BP), two psychiatric disorders with large epidemiological impacts, is a key research area in neurosciences and psychiatric genetics. Previous evidence from genome-wide studies suggests an important role for genes involved in synaptic plasticity in the risk for SZ and BP. We used a convergent genomics approach, combining different lines of biological evidence, to identify genes involved in the cAMP/PKA/CREB functional pathway that could be novel candidates for BP and SZ: CREB1, CREM, GRIN2C, NPY2R, NF1, PPP3CB and PRKAR1A. These 7 genes were analyzed in a HapMap based association study comprising 48 common SNPs in 486 SZ, 351 BP patients and 514 control individuals recruited from an isolated population in Northern Sweden. Genetic analysis showed significant allelic associations of SNPs in PRKAR1A with SZ and of PPP3CB and PRKAR1A with BP. Our results highlight the feasibility and the importance of convergent genomic data analysis for the identification of candidate genes and our data provide support for the role of common inherited variants in synaptic genes and their involvement in the etiology of BP and SZ.

KEYWORDS:

Genomics; Neural plasticity; Psychiatric genetics; Synaptic genes

PMID:
26899345
DOI:
10.1016/j.schres.2016.02.012
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center