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World J Biol Psychiatry. 2016;17(2):140-6. doi: 10.3109/15622975.2015.1126676. Epub 2016 Feb 9.

Analysis of association between common variants in the SLCO6A1 gene with schizophrenia, bipolar disorder and major depressive disorder in the Han Chinese population.

Khan RA1,2, Chen J1,3, Wang M1, Wen Z1, Shen J1, Song Z1, Li Z1, Wang Q1, Li W1, Xu Y3, Ji W4, Shi Y1,4,5.

Author information

1
a Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) , and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University , Shanghai , 200030 , P.R. China ;
2
e Dept. Of Chemistry , University of Azad Jammu and Kashmir , Muzaffarabad , 13100 , Pakistan.
3
b Shanghai Key Laboratory of Psychotic Disorders , Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine , Shanghai , 200030 , P.R. China ;
4
c Shanghai Changning Mental Health Center , 299 Xiehe Road , Shanghai , 200042 , P.R. China ;
5
d Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University , Shanghai , 200042 , P.R. China ;

Abstract

OBJECTIVES:

The SLCO6A1 gene belongs to a superfamily of genes which is known to be a solute carrier family of OATPs (SLCO). The SLCO6A1 gene encodes OATP6A1 protein in humans. A previous genome-wide association study (GWAS) of schizophrenia conducted in the Swedish population demonstrated a significant association of rs6878284, which is located in the SLCO6A1 gene, with schizophrenia. To further investigate whether this gene is also a risk locus for schizophrenia (SCZ), bipolar disorder (BPD) and major depressive disorder (MDD) in the Han Chinese population, a case-control study was designed.

METHODS:

In total 1,248 unrelated SCZ cases, 1,344 BPD cases, 1,056 unrelated MDD cases and 1,248 normal controls were analysed in this study. We genotyped five SNPs using the Sequenom MassARRAY platform.

RESULTS:

We found no association of rs6878284 with SCZ [Corrected Pallele = 0.969, Corrected Pgenotype = 0.997]. Furthermore, we found a statistically significant association of the rs7734060 genotype with MDD after correction [rs7734060: Corrected Pallele = 0.114, Corrected Pgenotype = 0.036] in the Han Chinese population.

CONCLUSIONS:

This is the first study which reveals no association of rs6878284 with SCZ and also predicts that rs7734060 could be a risk locus for MDD in the Han Chinese population.

KEYWORDS:

Han Chinese; Major depressive disorder; SLCO6A1; case–control study; genetic association

PMID:
26861727
DOI:
10.3109/15622975.2015.1126676
[Indexed for MEDLINE]

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