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Eur Urol. 2016 Nov;70(5):718-721. doi: 10.1016/j.eururo.2016.01.028. Epub 2016 Feb 3.

Phase 1b Study of Abiraterone Acetate Plus Prednisone and Docetaxel in Patients with Metastatic Castration-resistant Prostate Cancer.

Author information

1
Weill Cornell Medical College and Meyer Cancer Center, New York, NY, USA. Electronic address: stt2007@med.cornell.edu.
2
Cedars-Sinai Medical Center, Los Angeles, CA, USA.
3
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
4
Columbia University Medical Center, New York, NY, USA.
5
Yale Cancer Center, New Haven, CT, USA.
6
Janssen Research & Development, Los Angeles, CA, USA.
7
Janssen Research & Development, San Diego, CA, USA.
8
Janssen Research & Development, Beerse, Belgium.
9
Janssen Research & Development, Raritan, NJ, USA.
10
Weill Cornell Medical College and Meyer Cancer Center, New York, NY, USA.

Abstract

Coadministration of docetaxel and abiraterone acetate plus prednisone (AA + P) may benefit patients with metastatic castration-resistant prostate cancer (mCRPC) because of complementary mechanisms of action. COU-AA-206 was a phase 1b study to determine the safe dose combination of docetaxel and AA + P in three cohorts of chemotherapy-naïve mCRPC patients. Twenty-two patients received escalating doses of docetaxel plus AA + P. The primary endpoint was the proportion of patients with a dose-limiting toxicity (DLT) between weeks 2 and 7. The recommended phase 2 dose (RP2D) was the highest safe combination of docetaxel plus AA + P. Prostate-specific antigen (PSA) changes and intensive pharmacokinetic parameters for each drug were evaluated. Docetaxel 75mg/m2 + AA 1000mg + P 10mg was deemed the RP2D, with DLT in one of six patients. PSA declines from baseline of ≥50% and ≥90% were observed for 85.7% and 66.7% of patients, respectively. During median follow-up of 14.5 mo, eight patients had PSA progression and six had radiographic progression or died. Systemic exposure was comparable for docetaxel and abiraterone when given alone or in combination. Studies are ongoing to confirm the efficacy of potent androgen receptor-targeted therapy plus taxane in early mCRPC.

PATIENT SUMMARY:

The combination of hormonal therapy and chemotherapy may improve outcomes in men with metastatic prostate cancer. This study demonstrates the ability to combine the hormonal therapy agent abiraterone acetate, plus prednisone, and the chemotherapy drug docetaxel with an acceptable side effect profile. A high rate of prostate-specific antigen decline was seen, but the study was small and additional research is needed before this becomes a standard approach.

KEYWORDS:

Abiraterone acetate; Androgen receptor; Combination; Docetaxel; Drug-drug interaction; Metastatic castration-resistant prostate cancer; Pharmacokinetics; Safety; Toxicity

PMID:
26852075
DOI:
10.1016/j.eururo.2016.01.028
[Indexed for MEDLINE]

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